I - Clinical Details in 5 Liver Transplant Recipients at Time of Erythromycin Breath Test
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چکیده
low flow to the left hemisphere. These indications of low neural activity in the left hemisphere are consistent with early reports on lateralised features in the EEG in dysphasia.17 In conclusion, we have shown that various developmental learning disabilities are associated with regional cerebral blood flow abnormalities as assessed with SPET. It may be that the phylogenetically recent linguistic functions are vulnerable to slight disturbances in regional cerebral activity whereas attention control, a primitive capacity important for survival, is protected from such changes.
منابع مشابه
[C]erythromycin breath and urine test
Lemahieu, W. P. D., B. D. Maes, Y. Ghoos, P. Rutgeerts, K. Verbeke, and Y. Vanrenterghem. Measurement of hepatic and intestinal CYP3A4 and PGP activity by combined po iv [14C]erythromycin breath and urine test. Am J Physiol Gastrointest Liver Physiol 285: G470–G482, 2003; 10.1152/ajpgi.00028.2003.—The aim of the present study was to develop a test for measuring hepatic and intestinal removal of...
متن کاملMeasurement of hepatic and intestinal CYP3A4 and PGP activity by combined po + iv [14C]erythromycin breath and urine test.
The aim of the present study was to develop a test for measuring hepatic and intestinal removal of cytochrome p-450 3A4 (CYP3A4)- and P-glycoprotein (PGP)-dependent xenobiotics that would be applicable for clinical use in humans. Orally and intravenously administered [N-methyl-14C]erythromycin was used for evaluation of 14C-labeled excretion dynamics in breath and urine. Simultaneous breath and...
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Tacrolimus, a cornerstone of immunosuppressive therapy in solid organ transplantation, has a narrow therapeutic range with considerable inter-individual and intra-individual pharmacokinetic variability. To date, there is no information on the pharmacokinetics of tacrolimus in Iranian liver transplant recipients. This study was designed to determine pharmacokinetic properties of orally administe...
متن کاملClinical Pharmacokinetics of Tacrolimus in Iranian Liver Transplant Recipients
Tacrolimus, a cornerstone of immunosuppressive therapy in solid organ transplantation, has a narrow therapeutic range with considerable inter-individual and intra-individual pharmacokinetic variability. To date, there is no information on the pharmacokinetics of tacrolimus in Iranian liver transplant recipients. This study was designed to determine pharmacokinetic properties of orally administe...
متن کاملP450 3A activity and cyclosporine dosing in kidney and heart transplant recipients.
Interpatient differences in the kinetics of cyclosporine appear to result in part from interindividual differences in the catalytic activity of an enzyme termed P450 3A. We investigated the relationship between P450 3A activity, as measured by the erythromycin breath test (ERMBT), and the appropriate stable daily dose of cyclosporine as currently determined by physicians at our institution. The...
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تاریخ انتشار 2003